Liposomes, especially cationic liposomes, are the most widely used drug/gene delivery nanocarriers. Based on their biocompatible composition, they can be designed to carry a variety of different drugs, ensuring the local accumulation of the drug in specific tissues or even within the target cells. Upon entry into the circulatory system, liposome nanoparticles (LNPs) encounter a protein-rich environment that may adsorb to liposomes to form so-called protein crown (corona in Latin), which may control the interaction of liposomes with tissues and cells.
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