A serious and frequently fatal condition known as pulmonary hypertension (PH) is characterised by aberrant vascular remodelling and proliferation of the tiny pulmonary arteries and arterioles, vasoconstriction, and in situ thrombosis. PVR (pulmonary vascular resistance) gradually rises as a result, and right ventricular failure eventually results. Intimal thickening, concentric hypertrophy, and perivascular fibrosis of distal pulmonary arterioles are the main histological characteristics of the PH vasculopathy.
The tiny pulmonary arterioles are the main sites of the lung vascular disorder known as pulmonary arterial hypertension (PAH). During a right heart catheterization, PH is defined as a mean pulmonary artery pressure greater than 25 mm Hg. A subset of individuals with pulmonary artery wedge pressure less than 15 mm Hg and pulmonary vascular resistance larger than 3 Woods units are referred to as having PAH. They also have pre-capillary hypertension. Idiopathic, hereditary, and pulmonary arterial hypertension linked to risk factors or associated illnesses are the three subgroups of PAH.
Global pulmonary arterial hypertension market- Segment analysis
By drug type
- Endothelin Receptor Antagonists (ERAs)
- PDE-5 Inhibitors
- Prostacyclin and Prostacyclin Analogs
- SGC Stimulators
- Others
The prostacyclin and prostacyclin analogs segment is anticipated to garner significant returns over the forecast duration. This is credited to the escalating demand of this drugs due to their efficacy and easy approval process.
By route of administration
- Oral
- Intravenous/subcutaneous
- Inhalational
The oral segment is presently dominating the market in terms of revenue share ascribing to the rising availability of oral formulations and surging patient preference for oral medicines.
By distributional channel
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
The online pharmacies segment is slated to register notable gains over 2022-2030 due to increase in internet penetration and widespread adoption of smart devices.
Global pulmonary arterial hypertension- Geographical landscape
Considering the geographical frame of reference, the business sphere is divided into North America, Middle East Africa, Latin America, Europe, and Asia Pacific. Among these, North America is projected to showcase lucrative expansion trends over 2022-2030 attributing to growing cognizance of PAH, favorable medical reimbursement policies, and surging prevalence of infectious and chronic diseases.
Also, Asia Pacific is anticipated to amplify with a significant CAGR owing to the presence of prominent pharmaceutical companies, surging consumption of generics, and rapidly evolving healthcare infrastructure in nations such as China, India, and Japan.
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Top Key Players:-
- Bayer AG
- GlaxoSmithKline plc
- Johnson Johnson (Actelion Pharmaceuticals, Ltd.)
- Merck Co., Inc
- United Therapeutics Corporation
- Gilead Sciences, Inc.
- Sandoz AG (Novartis)
- Lupin
- Teva Pharmaceutical Industries Ltd.
- Lilly and Company
- DAIICHI SANKYO COMPANY, LIMITED
- Reddy’s Laboratories Ltd.
- Par Pharmaceutical
- Zydus Pharmaceuticals, Inc.
- Hikma Pharmaceuticals PLC
- Mylan N.V.
- Sigmapharm Laboratories, LLC.
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Frequently Asked Questions (FAQ):
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