In addition, most natural products are complex in structure and cumbersome to produce on a large scale using chemical synthesis routes with low yields, high energy consumption and heavy pollution, making it difficult to achieve environmentally friendly production. Therefore, BOC Sciencesuses total synthesis, semi-synthesis or biosynthesis to produce natural products, and structural modifications to reduce the toxicity and improve the activity of natural products.
Background
The structures of natural products are complex and some of them cannot be synthesized or are very costly to synthesize. In addition, natural products themselves are not always the most desirable molecules for medicinal purposes and can be structurally modified and modified to obtain more useful molecular analogs of natural products. It is also possible to use natural products as lead compounds to design smaller compounds with simpler structures as synthetic substitutes for natural products. Some intermediates for the synthesis of natural products may also become useful medicinal molecules. We develop and produce various important natural medicinal products by synthetic means using natural products as raw materials.
Our Services
BOC Sciencescan provide our customers with the following ways of custom natural products synthesis and natural products modification.
Service contents
The structure of natural products is complex, and some are not synthesized or are costly to synthesize. In addition, the natural product itself is not always the most desirable molecule for medicinal use, and can be structurally modified and modified to obtain more useful molecular analogs of the natural product. It is also possible to use natural products as lead compounds to design smaller compounds with simpler structures as synthetic substitutes for natural products. Some intermediates for the synthesis of natural products may also become useful medicinal molecules. The development and production of drugs by synthetic means, using natural products as the source or lead, occupies an important position in the pharmaceutical and related industries.
For some natural compounds with complex structures, it is difficult to obtain them by synthetic methods, or the reaction is complicated and the yield is low without industrial production value. Semi-synthesis of natural products uses natural and non-natural readily available structural analogues or intermediates obtained by structural modification of natural products as raw materials, and then synthesizes them in several steps to prepare useful natural products and their derivatives.
Scientific design and reconstruction of complete systems for the efficient and rapid production of medicinal active ingredients by modifying microorganisms or plants already present in nature or in these organisms. The strategy entails first speculating the biosynthetic pathway of the target natural product, then identifying the key enzymes and cofactors required for each catalytic reaction step, then integrating the biosynthetic pathway into the stromal cell, and finally optimally regulating the entire metabolic network.
While natural products can certainly be used directly for medicinal purposes, there are issues such as resources, cost, activity, toxicity, and physicochemical properties. Therefore, the development of derivatives or synthetic substitutes of natural products with higher activity, lower toxicity, superior physicochemical properties and lower cost is one of the main ways to develop new drugs today, taking natural products as the first step.
Source: https://natuprod.bocsci.com/services/custom-synthesis-services-of-natural-products.html
