Paclitaxel works by inhibiting the function of microtubules. It binds to the tubulins which are the building blocks of microtubules. This as a result does not let microtubule and paclitaxel disassemble and hence induces cell death in the cancer cells. Paclitaxel is bound to albumin as it is an effective way for the cancer cells to uptake the medication. It also reduces the toxic effects that are associated with other forms of paclitaxel. Paclitaxel 100mg injection is given as an intravenous injectable suspension.
Some of the precautions to remember while using paclitaxel are –
· Some components of paclitaxel can cause an allergic reaction in patients. It is also possible for the patient to be allergic to albumin. Therefore, it is advisable to consult the doctor regarding this and gather complete information about the injectable before use.
· Inform the doctor about all the past medical conditions, especially kidney, liver or heart disease.
· Paclitaxel can harm the fetus hence it is advisable to avoid pregnancy during and till six months after the last dose of the treatment.
· Paclitaxel can interact with vitamin supplements and other medications like carbamazepine and HIV drugs.
· It is advisable to avoid breastfeeding during and till two weeks after the last dose.
Side effects of albumin-bound paclitaxel –
· Redness, rashes and itching
· Injection site reaction
· Sores in mouth
· Dry mouth
· Muscle and joint pain
· Nausea, diarrhoea and vomiting
· Unusual bruises
· Increased bleeding
· Chest pain
· Irregular or slow heart rate
· Shortness of breath
· Tingling of hands and arms
· Difficulty in swallowing
· Fainting and extreme fatigue
· Swelling of eyes, mouth and tongue
· Excessive thirst
· Hair loss
· Vision complications
Conclusion
Protein-bound paclitaxel is an effective medication for the treatment of ovarian cancer as well as breast cancer and lung cancer. Although the price of Paclitaxel is high, it can be obtained from Magicine Pharma at an affordable rate.
Source Url: Paclitaxel 100 mg Injection
