Liposomes, especially cationic liposomes, are the most widely used drug/gene delivery nanocarriers. Based on their biocompatible composition, they can be designed to carry a variety of different drugs, ensuring the local accumulation of the drug in specific tissues or even within the target cells. Upon entry into the circulatory system, liposome nanoparticles (LNPs) encounter a protein-rich environment that may adsorb to liposomes to form so-called protein crown (corona in Latin), which may control the interaction of liposomes with tissues and cells.
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Membrane proteins play an essential role in life activities. In the sequenced genome, membrane proteins account for 30% of drug-targeted sites. Functions such as signal transmission between cells and detection of the external environment are mostly realized through special membrane receptor proteins on biological membranes. Many human diseases are related to the abnormal function of these membrane proteins.
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